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Project: Influence of Notch on human T cell differentiation

project duration
01-JAN-03 – 31-DEC-06
abstract
In this project we will address the role of Notch and HES-1 on human T cell differentiation. We will with the use of gamma secretase inhibitors investigate whether inhibition of notch signaling interferes with human T cell differentiation. In addition we will by retrovirally transduction of the active form of Notch or HES-1 investigate how activation of Notch influences T cell differentiation. We will use the fetal thymus organ culture to monitor the differentiation of human thymocytes starting from immature progenitors.