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Project: Target cells in which and mechanism how the US3 protein kinase of alphaherpesviruses interferes with the antiviral immune response

project duration
01-JAN-06 – 31-DEC-09
abstract
The multifunctional viral US3 protein kinase is conserved among alphaherpesviruses. We and others have shown that US3 displays anti-apoptotic properties and induces a rearrangement of the cytoskeleton. The main objective of the project is to assess whether these and other properties of US3 allow alphaherpesviruses to interfere with the antiviral immune response, and in which cells and how this interference is induced.