Project: Interrelationship of pulmonary inflammation, systemic inflammation and airway remodelling in the pathogenesis of Chronic Obstructive Pulmonary Disease (COPD).
- project duration
- 01-JAN-09 – 31-DEC-12
- The overall aim of this coordinated, multidisciplinary research proposal is to elucidate the interrelationship between systemic inflammation, pulmonary inflammation and airway remodelling in the pathogenesis of COPD. The central hypothesis is that "COPD ensues from an inappropriate (ie exaggerated, harmful) inflammatory and/or fibrogenic response of the host to cigarette smoke".