Project: Identification and structure-function analysis of novel cytoplasmic lysophoshatidic acid (LPA)-binding proteins and their implementation as fluorescent intracellular detection probes
- project duration
- 01-JAN-05 – 31-DEC-08
- Proteins that interact with LPA are isolated by affinity chromatography on a solid matrix and identified by mass spectrometry (LPA lipidomics). Their interaction with LPA will be analyzed in depth using biophysical methods as well as in living cells using fluorescent proteins. This way we can investigate intracellular dynamics of certain lipids against which no antibodies are available.