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Project: Analysis of leptin-mediated gene regulation in vitro an in vivo.

01-JAN-99 – 31-DEC-02

In this program we plan to evaluate signaling, leading to gene regulation, emanating from the leptin receptor. By an in vitro approach using PC12 cells transfected with the leptin receptor, a collection of genes modulated by leptin will be identified. On the basis of a series of in vitro approaches, gene regulation will be studied in great detail. The obtained data set will allow us to select genes for in vivo studies, including gene knock-outs. Effects on metabolism will be assessed.