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Project: Analysis of leptin-mediated gene regulation in vitro an in vivo.

project duration
01-JAN-99 – 31-DEC-02
abstract
In this program we plan to evaluate signaling, leading to gene regulation, emanating from the leptin receptor. By an in vitro approach using PC12 cells transfected with the leptin receptor, a collection of genes modulated by leptin will be identified. On the basis of a series of in vitro approaches, gene regulation will be studied in great detail. The obtained data set will allow us to select genes for in vivo studies, including gene knock-outs. Effects on metabolism will be assessed.