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Project: Extracellular matrix and growth factors during the wound healing of sinusal and nasal mucosa.

01-JAN-01 – 31-DEC-01

Quality of wound healing is essential in sinus surgery. Coagulation, inflammatory reaction, proliferation of epithelium and extracellular matrix and remodeling interact in the mucosa during healing. The project describes histomorphologically and biochemically the healing process in human respiratory mucosa after sinus surgery and searches for modulating factors. Proinflammatory cytokines, TGF-Beta and extracelullar matrix protein fibronectin are of particular interest.