Project: Evaluation of flow cytometry as a tool to study extracellular matrix repair by human articular chondrocytes obtained from normal and osteoarthritic cartilage. Influences of pharmacologic agents.
- project duration
- 01-JAN-01 – 31-DEC-03
- The use of antigen specific proteins (monoclonal antibodies,…) directed against extracellular matrix (ECM) molecules allowed chondrocyte plasmamembrane-bound antigens to be studied using FACS scan analysis. The next project would concentrate on the homeostasis of the ECM and the differences between normal chondrocytes and chondrocytes obtained from osteoarthritic articular cartilage. The mechanisms lying behind an abnormal/pathological metabolism will be investigated. A second part of this research programme would cover the influences of pharmacological substances on the abnormalities observed in osteoarthritic cartilage cells.