Project: Regulation and function of CARD15 in primary intestinal epithelial and mononuclear cells in normal and pathologic conditions
- project duration
- 01-JAN-05 – 31-DEC-08
- Primary human epithelial and mononuclear cells will be isolated from ileal and colon biopsies. The regulation and function of CARD15 protein will be studied after immortalisation of the cellines by ectopic expression of human telomerase reverse transcriptase. The cellular response to pathogenic and inflammatory products will be studied.