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Project: Identification of apoptosis-inducing cell surface receptors of human thymocytes.

project duration
01-JAN-99 – 31-DEC-02
abstract
Monoclonal antibodies that induce apoptosis of human thymocytes, independent of, or in combination with TCR/CD3 triggering, will be used to identify the cell membrane antigens responsible for programmed cell death. We plan to use : 1) immunoselection of prokaryotic and eukaryotic cells transfected with a cDNA library of human thymocytes, and 2) 2D gel electroforesis, amino acid sequence determination and nucleic acid hybridisation.