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Project: Analysis of molecular interactions of SOCS proteins

01-JAN-06 – 31-DEC-09

SOCS proteins are negative regulators of cytokine signaling. Many aspects of their mechanism of action remain ill-defined. This study aims at (1) the analysis of inter-SOCS interactions, (2) structure/function analysis of designated SOCS interactions, (3) functional analysis of SOCS/receptor systems, and (4) MAPPIT screens using slected SOCS subdomains and variants.