Project: Analysis of molecular interactions of SOCS proteins
- project duration
- 01-JAN-06 – 31-DEC-09
- SOCS proteins are negative regulators of cytokine signaling. Many aspects of their mechanism of action remain ill-defined. This study aims at (1) the analysis of inter-SOCS interactions, (2) structure/function analysis of designated SOCS interactions, (3) functional analysis of SOCS/receptor systems, and (4) MAPPIT screens using slected SOCS subdomains and variants.