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Project: Analysis of signaling via the leptin receptor

01-JAN-03 – 31-DEC-06

Leptin is a cytokine that functions as a "lipostat", i.e. the afferent signal in a negative feedback loop, with the hypothalamus as central organ. This program aims at (1) analysis of laptin / leptin-receptor complex formation (2) mutation analysis of the leptin receptor it focus on negative feedback mechanisms (3) MAPPIT screens for novel components in leptin signaling and (4) in vivo analysis of the latter.