Project: Investigation into the pathogenesis of airway remodelling in asthma.
- project duration
- 01-JAN-98 – 31-DEC-00
- Airway remodelling encompasses the structural airway changes that occur in chronic asthma. The objectives of the study is to evaluate the importance of specific cytokines (TNF, IL-1) and growth factors (PDGF, TGF-beta, GMCSF, IgF) in the pathogenesis of airway remodelling. The study will be conducted partly in man (detection of cytokines in sputum samples from asthmatics), partly in an in vivo rat model of airway remodelling.