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Project: Development of a small animal model for the study of hepatitis B virus (HBV) in hepatitis C virus (HCV) infections.

project duration
01-JAN-00 – 31-DEC-03
abstract
Research about the role of thje immune system in the elimination of HBV and HCV and their evolution towards chronicity is hampered by the lack of an affordable and reliable animal model. In this project we wish to create such an animal model by using severe combined immunodeficient (SCID) mice, human lymphoid cells and human hepatocytes. Such a model should allow us to examine the role of the human immune system in the pathogenesis of hepatocellular damage in viral hepatitis.