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Project: Assessment of substrate binder interactions in model granule systems and in real granule systems.

01-JAN-98 – 31-DEC-00

The aim of the project is to assess the binder-substrate interactions in solid dosage forms more specifically in wet granulation systems. Models as well as real granulation systems are investigated. The models used are glass spheres and fibers with parecetamols of different geometry and particle size are used as real systems. The parameters investigated are : porosity, total surface area, flow properties, SEM, agglomerate strength and fracture analysis.