Project: Interactions of psychotropic agents at the level of cytochrome P450 isoenzymes.
- project duration
- 01-JAN-97 – 31-DEC-00
- The selective serotonine reuptake inhibitors (SSRI's) will be studied, as possible inhibitors of some cytochgrome P450 isoenzymes, on the metabolism of a number of cardiovascular drugs, terfenadine and haloperidol which might be possible victims of such interactions. In vitro studies will be done with human microsomes. In the in vivo studies, the influence of concomitant intake of SSRI's in patients taking victim substances will be studied on their plasma concentrations.