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Project: A profound study of the anti-inflammatory condition of the mouse strain SPRET/Ei, with emphasis on the glucocorticoidreceptor and the X chromosome

01-JAN-10 – 31-DEC-13

The LPS-resistance of SPRET/Ei is genetically linked to chromosomes 2 and X, and dependent on higher glucocortiod receptor expression levels. We want to search for the basis of this higher expression, and the relation with the loci on chromosomes 2 and X. We also want to study the X-locus in more detail, to possibly identify a protecting gene.