Project: Application of novel tools and insights to understand the exact role
of TNF in polymicrobial sepsis and to develop an efficient therapy.
- project duration
- 01/10/15 – 30/09/17
- In this project, the exact role of TNF in polymicrobial sepsis will be studied. We hypothesize that
TNF has a double role in sepsis, namely a “good” and a “bad” role and thus that inhibition of TNF
leads to no therapeutic results. We believe that specific inhibition of TNFR1 on the relevant cells, combined with a cell-specific targeting of TNF and GC treatment can form the basis of a new therapy for sepsis.