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Project: QSAR directed design, synthesis and evaluation of anti-invasive chalcones and related heterocyclic compounds

project duration
01-OCT-08 – 30-SEP-12
abstract
Invasion and metastasis are the foremost causes of the fatal outcome of cancer and accordingly pose a main challenge in oncology. Using a predictive QSAR-model as a rationale and an in vitro assay as verification, the objective of this project is to synthesise new potent anti-invasive agents amongst the classes of chalcones and related heterocyclic compounds.