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Project: In vivo evaluation of non-viral mRNA delivery systems for mRNA vaccination against cancer.

project duration
01-OCT-09 – 30-SEP-11
abstract
We will evaluate non-viral delivery systems for mRNA vaccination against cancer in mouse-models. Therefore, we will first study the biodistribution, the level and the kinetics of the gene expression of mRNA/liposome or mRNA/polymer complexes in mice. Additionally, the immunological response and tumor growth will be evaluated after the delivery of a mRNA vaccine complexed with the most efficient non-viral delivery system.