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Project: Alternative pathways of cellular CD4 trafficking and functional relevance in hematopoietic cells

01-OCT-10 – 30-SEP-12

The CD4 receptor expressed on hematopoietic cells is essential in T cell development and activation and is down-modulated during T cell activation or pathological conditions like HIV-1 infection, but the process is still poorly understood. In this project, genes involved in CD4 down-modulation identified by a genome-wide shRNA screening are validated and evaluated for their functional relevance in hematopoietic cells.