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Project: Investigation of the spermfactor phospholipase C zeta associated with failed fertilization

project duration
01-OCT-09 – 30-SEP-11
abstract
Failed fertilisation following intracytoplasmic sperm injection is mainly due to an oocyte activation defect. The sperm-specific phospholipase C zeta is the responsible factor. Its localisation, expression and genetics will be studied in activation deficient sperm. Furthermore we will create a knock-out mouse model for this factor, test different artificial oocyte stimulation ways and subsequently use these in human oocytes.