Project: Priming stimulation: a multimodal approach to evaluate the effects of theta-burst transcranial magnetic stimulation priming on prefrontal cortex functioning in healthy and depressed individuals
2020-11-01 – 2025-10-31
- Abstract
Intermittent theta-burst stimulation (iTBS) has been increasingly used to target prefrontal brain regions, such as the dorsolateral prefrontal cortex (DLPFC), to optimize therapeutic outcomes in patients suffering from major depressive disorder. However, despite the promising outcomes, clinical efficacy remains rather modest. Interestingly, fundamental research targeting the motor cortex has suggested the use of priming techniques to enhance iTBS-related changes in cortical excitability. Hence, TBS priming - using a prime TBS protocol to enhance the effects of a subsequent test TBS protocol - can yield improved iTBS efficacy when applied over the prefrontal cortex. Moreover, recent developments in the field indicate that stimulation priming can be highly efficacious in reducing depressive symptoms. However, the mechanisms of action remain to be explored. This research project aims to investigate the effects of TBS priming applied to the DLPFC and the mechanisms by which TBS priming modulates prefrontal cortex functioning. The effects of iTBS alone and in combination with a TBS prime will be assessed by using a multimodal approach, consisting of neuroimaging, psychophysiological and behavioral assessments, to operationalize changes in prefrontal cortex excitability and deepen the insight into the mechanisms through which TBS priming modulates cognitive and affective processes that are related to DLPFC functioning.
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- Journal Article
- open access
Differential Effects of Cerebellar tDCS on Sequential Mentalizing
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Brain state dependence of prefrontal non-invasive brain stimulation : insights and clinical implications
(2025) -
- Journal Article
- A1
- open access
Cognitive appraisal modulates Theta Burst Stimulation effects on stress-reactive rumination and affect
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- Journal Article
- open access
Investigating the neural and behavioral correlates of the stress-rumination link in healthy humans by modulating the left Dorsolateral Prefrontal Cortex using Theta Burst Stimulation
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Mood induction by reliving memories – impact on mood state and cerebral perfusion
(2025) -
- Journal Article
- A1
- open access
Investigating cerebral blood flow in anxious dogs : a 99mTc-HMPAO SPECT imaging study
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- Journal Article
- A1
- open access
Affective state-dependent effects of prefrontal rTMS on the cognitive control of negative stimuli in healthy and depressed individuals
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- Journal Article
- A1
- open access
Assessing accelerated iTBS in treatment-resistant melancholic depression : doubling the number of pulses per session does not double the response rates
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- Miscellaneous
- open access
The combination of physical exercise and slow-paced breathing on psychophysiological indices of emotion reactivity, psychosocial stress and recovery : a multimodal investigation
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Affective state-dependent effects of prefrontal rTMS on the cognitive control of negative stimuli in healthy and depressed individuals