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Project: Identification and validation of molecular mechanisms involved in necrotic cell death

project duration
01-OCT-10 – 30-SEP-13
abstract
We aim to further dissect regulated necrosis, by means of high trouhgpu 5HT) and heigh content screening (HTS) using automated microscopy. The identified mechanism will eventually be validated by in vivo disease model systems in which necrotic ceel death mechanisms is presumed to play a major role (TNF-induces shick, inflammatory bowel disease, diabetes, ischemia/reperfusion).