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Project: Granzyme-mediated cell-targeted and antiviral methods-of-action: a targeted proteomic analysis

01-OCT-08 – 30-SEP-11

The COFRADIC or 'COmbined FRActional DIagonal Chromatography' technology specifically isolates peptides holding the amino terminal part of proteins. Since protein processing gives rise to a new protein fragment, isolation of N-terminal peptides points to proteolytic event and permit analysis of protein processing on a proteome-wide scale. The proteome-wide degradomics methods will be applied to study granzyme-mediated target and host-virus interactions.