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Project: Structure-function analysis of the human paracaspase MALT1 in antigen receptor induced signal transduction to NF-kB dependent gene expression

project duration
01-OCT-08 – 30-SEP-11
abstract
The paracaspase MALT1 plays an important role in activation of NF-kB through T- and B-cell receptors. The aims of this project are: 1) To identifty new substrates for MALT1 and to characterize their role. 2) To identify the molecular mechanisms that regulate MALT1 proteolytic activity.