Ghent University Academic Bibliography

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Project: Interactome and degradome analysis of signaling pathways leading to activation of the inflammasome complexes.

project duration
01-OCT-09 – 30-OCT-09
abstract
Ipaf, Nalp1 and Cryopyrin/Nalp3 zijn cytosolic Nod-like (NLRs) that are implicated in the stimulus-dependent assembly of large caspase-1-activating protein complexes called ' inflammasomes'. We will characterize the upstream signaling pathways that lead to activation of the inflammasomes by making use of making use of mass spectrometry-and MAPPIT-based degradomics and interactome analysis.