Ghent University Academic Bibliography

Advanced

Project: Induction of IgA2 class switching in human Ige+B cells as theraphy for allergic disease

project duration
01-OCT-09 – 30-SEP-12
abstract
Abstract (max. 60 woorden): IgE plays a central role in allergy by activating mast cells and facilitating allergen presentation to Th2 lympghocytes. Accumulating evidence suggests that IgA plays a protective role in allergy by antagonizing the effects of IgE. Therefore using three proven IgA promoting regimens: IL-21+TGFB1, cholera toxin B (CTB) and Lactococci engineerd to express allergen and CTB