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Project: Assessing the dynamic interplay between protein phosphorylation and O-linked-N-acetylglucosamine

01-OCT-08 – 30-SEP-11

The aim of this study is the development of a diagonal chromatographic based technology for the study of O-GlcNAc-modified proteins and its applications for the analysis of the dynamic interplay between O-GlcNAc-modifications and phosphorylation. Finally, the technology will be used for an in depth study to show the importance of O-glycosylation (O-GlcNAc) and phosphorylation in a model of necrotic cell death.