Ghent University Academic Bibliography


Project: Optimization of stability and dissolution on lyophilised drug formulations.

project duration
01-JAN-93 – 31-DEC-99
Most drugs from biotechnologic sources are formulated as lyophilised drug formulations. The project will try to answer the following questions: the importance of residual water amount and water activity in a lyophilised product and the importance ofthe secundary drying proces in that perspective, the influence of rubber closure structure on the water permeability the influence of changing freons on the development of formulations and processes and influence of sucrose-esters on crystal.process