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Project: Molecular Biological study of Cancer : Invasion/Metastasis and Tumour Necrosis Factor.

project duration
01-JAN-93 – 31-DEC-99
abstract
In addition to genes responsable for immortalisation and for achorage-independent growth, expression of one or more genes is necessary to convert a transformed into a cancer cell with invasive and metastatic properties. Systems will be developed aimed at the cloning of such additional genes.Tumour Necrosis Factor is on the one hand specifically toxic for malignant cells, but also toxic for the experimental animal or the patient.Is the mechanism of action the same in both systems?