Project: Identification and pathway analysis of direct and miRNA regulated MYCN target genes in neuroblastoma
- project duration
- 31-DEC-06 – 30-DEC-07
- Neuroblastoma is the most frequent extracranial solid tumour in children. Despite the existence of multimodal treatments, the prognosis of most patients remains unfavourable. A subgroup of agressive neuroblastoma tumours is characterised by amplification of the MYCN transcritpion factor. The identification of new MYCN target genes could result in improved treatment strategies.