Project: Innate immunity and the role of Staphylococcus aureus enterotoxines in cystic fibrosis
- project duration
- 01-APR-03 – 31-DEC-04
- We want to investigate the role of bacterial infection, especially by Staphylococcus aureus, and the possible role of direct bacterial triggering through innate receptors in the extensive neutrophilic inflammation, that is characteristic for upper and lower respiratory pathology in cystic fibrosis. The fast and non-clonal innate immune system is not only responsible for first-line bacterial clearance, but also triggers the adaptive immune system. We want to investigate whether alterations in the innate immune response might have an impact on the course of the inflammatory reaction in sinonasal pathology in cystic fibrosis patients.