Project: Identification & characterization of polymorphisms associated with PRNP expression in sheep & goat in order to develop a more efficient genotyping test for TSE resistance
- project duration
- 01-FEB-06 – 31-JAN-08
- The project is a continuation of project 160K2304. Identified polymorphisms will be characterized & validated by way of reporter gene analysis. Validated polymorphisms willb e used in an association study with TSE resistance/sensitivity. If a significant association can be found the polymorphism will be included in the development of a more efficient PRNP genotyping test in sheep. The same strategy will be used for the PRNP gene of goats. Since the full PRNP gene sequence of goats is not described yet, the first step will be to sequence the gene to novo.