Project: Investigation into the relationship between bronchial hyperresponsiveness and aiway inflammation.
- project duration
- 01-JAN-00 – 31-DEC-99
- 1) Animal experiments : the aim is to induce airway inflammation in rats, through endotoxin or antigen inhalation, and to evaluate the effect of this inflammation on bronchial responsiveness to a variety of mediators. Pharmacological modulation of both inflammation and responsiveness will be assessed. 2) Human studies : the aim is to correlate the degree of airway inflammation to clinical symptoms and bronchial responsiveness.