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Project: Immunocytochemical study of bêta-amyloid precursor protein (bêta APP) abd berve growth factor receptor (NGF-rec) expression in target muscle fibers in the rat.

project duration
01-OCT-94 – 31-DEC-99
abstract
Previous observations in so-called intermediate filament myopathie and target formations revealed focal expression of some epitopes of the bêta-APP in muscle fibers. We here investigare in rat muscle - which bêta-APP epitopes are expressed in targetformations - whether they are differentially induced by denervation or tenotomy - whether bêta-APP and the NGD-rec are coexpressed as previously suggested for the brain lesions observed in Alzheimer's disease.