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Project: Immunostimulation and immunosuppression at the intestinal mucosa of the pig.

project duration
01-OCT-94 – 31-DEC-99
abstract
It will be examined if binding of an antigen to receptors on the intestinal mucosa is important for the type of immune response which becomes induced namely immunostimulation or immunosuppression. Pigs with or without receptors for F4 fimbriae of enterotoxigenic Escherichia coli (ETEC) will be orally given F4 or F4 linked to the LT enterotoxin of ETEC. Receptors for LT are present in all piglets. Following immunisation the systemic and mucosal humoral immune response will be determined by Elisa and Elispot, the activated lymphocytes will be identified and the produced cytokines will be determined.