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Project: Enantioselective HPLC determination of drugs in plasma and tissues.

project duration
01-OCT-93 – 31-DEC-99
abstract
It is our aim to study the stereoselective serum binding and pharmacokinetics of verapamil, oxprenolol and other drugs in humans and animals. Species differences and the influence of young age, pregnancy, inflammation upon the serum binding and pharmacokinetics of these drugs will be studied. the enantioselective assay of these racemic drugs plays a major role in this study. Therefore, enantioselective assays will be developed using HPLC.