Ghent University Academic Bibliography

Advanced

Project: In vitro retroviral transduction of human hematopoietic stem cells holding T-cell precursor potential : study of the effects of expression of HIV-proteins on thymopoiesis.

project duration
01-JUL-97 – 31-DEC-99
abstract
The aims of this project are the analysis of expression of HIV-1 (co-)receptors in isolated human hematopoietic stem cells and thymocytes, the establishment of culture conditions that allow expansion and retroviral transduction of stem cells without compromising the T-cell precursus potential and finally expressing HIV proteins, presumed to affect thymopoiesis, in stem cells, followed by analysis of thymopoiesis.