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Project: Identification of the human tumor associated antigen recognized by the 14C5 monoclonal antibody, and development of cancer aspecific antibody derivatives for diagnosis and therapy

project duration
01-JAN-04 – 31-DEC-06
abstract
14C5 is a tumor specific antibody that inhibits the metastasis of cancer cells. The antigen is unknown. Preliminary experiments have identified the antigen as a complex. We will use affinity cromatography and immunoprecipitation to isolate the antigen for identification. Anitbody fragments will be developed and evaluated as radio-immunodiagnosticum or radio-immunotherapeuticum.