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Project: Identification and study of positional and functional candidate tumor suppressor genes in neuro-ectodermal tumors.

project duration
01-JAN-99 – 31-DEC-01
abstract
This project aims at the identification of positional and functional candidate tumor suppressor genes in neuro-ectodermal tumors. In a first phase the positional cloning of the breakpoints of a constitutional 1:17 translocation in a patient with neuroblastoma will be finalised. Different gene identification techniques will be employed for the identification of genes in the neighbourhood of both translocation breakpoints. Mutation analysis for twe candidate genes (RIZ and TP53) will be conducted on a panel of neuro-ectodermal tumors and cell lines such as neuroblastoma and Merkel cell carcinoma.