Project: A mycobacterium bovis BCG transposon insertion library as a tool to study the role of mycobacterial glycolipids and other components in pathogenesis.
01-JAN-09 – 31-DEC-11
We aim at improving the protectieve efficacy of the M. bovis BCG vaccine against M.tb infection. We have generated an ordered M. bovis BCG transposon insertion library and selected mutants for further study. These mutants are characterizing biochemically and evaluated as TB vaccines in a stringent animal model. We're thoroughly studying immune responses upon infection, which mainly determine vaccine potential.