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Project: Analysis of SIP1 (Smad interacting protein-1) as an invasion inducer in carcinomas.

01-JAN-02 – 31-DEC-04

SIP-1 was shown to be a transcriptional repressor of the invasion/tumor-suppressor protein E-cadherin. SIP1 induces loss of cell adhesion and invasion and shows strong expression in malignant cancer cells. We aim at a better understanding of the role of SIP1 during tumor progression. With use of model cell systems with conditional SIP1 expression and transcriptprofiling with cDNA microarrays we will try to identify target genes regulated by SIP1 besides E-cadherin. The role of these genes during tumorprogression will be examined.