Project: Expression of iNOS and its inducing cytokines in the inflammatory myopathies.
- project duration
- 01-JAN-02 – 31-DEC-04
- Nitric oxide synthases (NOS) are responsible for the production of NO, an important bio-active molecule involved in intracellular signal transduction, immunological processes, vasodilatations and neuronal transmission. Increased NO production is believed to have a key function in the pathogenesis of auto-immunity. In the inflammatory myopathies, the presence of the three NOS isoforms, and of iNOS-inducing cytokines, will be explored.