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Project: Acquire cDNA libraries to do functional genetic studies to the LPS resistance of SPRET/Ei

01-JAN-06 – 31-DEC-08

The basis of this project is the extreme an dominant resistance of SPRET/Ei mice against LPS induced lethal shock. By differential expression studies we try to find some candidate genes. With the aid of a SPRET/Ei cDNA library we will sequence these genes, overexpress them in LPS sensitive mice and do functional genetic studies.