Project: Acquire cDNA libraries to do functional genetic studies to the LPS resistance of SPRET/Ei
- project duration
- 01-JAN-06 – 31-DEC-08
- The basis of this project is the extreme an dominant resistance of SPRET/Ei mice against LPS induced lethal shock. By differential expression studies we try to find some candidate genes. With the aid of a SPRET/Ei cDNA library we will sequence these genes, overexpress them in LPS sensitive mice and do functional genetic studies.