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Project: Identification and cloning of new genes involved in regulating the response on Tumor Necrosis Factor by a mouse molecular genetic approach.

project duration
01-JAN-00 – 31-DEC-02
abstract
In this project, we want to identify and clone the genes responsible for resistance against Tumor Necrosis Factor (TNF)-induced lethal inflammation. TNF plays a central role in a lot of pathologies and induces lethal cardiovascular shock and inflammation. Because of the antitumor activities of TNF, it is important to be able to control the TNF-induced toxicity. Several TNF-resistant strains of mice were identified. The genetic basis of the resistance will be investigate in this project.