Project: Cellular co-factors of HIV: protein-protein interactions as novel drug targets
- project duration
- 01-DEC-07 – 30-NOV-11
- Our objective is to increase basic understanding of protein-protein interactions, to develop technology to identify and validate protein-protein interaction relevent for human disease and to develop assays and evaluate inhibitors of protein-protein interaction. Specifically, we want to develop novel treatment strategies for HIV infection by targeting cellular co-factors involved in HIV replication: Lens Epithelium Derived Growth Factor (LEDGF/p75) and Nef.