Project: IRES-mediated initiation of translation during cellular stress.
- project duration
- 01-JAN-02 – 31-DEC-05
- Global cap-dependent translation is inhibited during cellular stress. Nevertheless binding of ribosomes to an internal binding site (IRES) in specific mRNA species can result in efficient translation. Our goal is to identify new IRES-sequences which can contribute to efficient translation of crucial mRNA's during hypoxia. The mechanism of the identified IRES-sequences will also be investigated.