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Project: Modification of the N-glycosylation pathway of Aspergillus niger for the production of more human-like recombinant therapeutic glycoproteins.

project duration
01-OCT-99 – 30-SEP-03
abstract
During this project the N-glycosylation pathway of the filamentous fungus A. niger is modified in order to obtain complex type N-glycans. This modification is accomplished by introducing genes coding for enzymes involved in the N-glycan synthesis in higher eukaryotes. The effect of the changed glycosylation will be studied by evaluating the function of in A. niger produced glycosylated cytokines.