Project: Modification of the N-glycosylation pathway of Aspergillus niger for the production of more human-like recombinant therapeutic glycoproteins.
- project duration
- 01-OCT-99 – 30-SEP-03
- During this project the N-glycosylation pathway of the filamentous fungus A. niger is modified in order to obtain complex type N-glycans. This modification is accomplished by introducing genes coding for enzymes involved in the N-glycan synthesis in higher eukaryotes. The effect of the changed glycosylation will be studied by evaluating the function of in A. niger produced glycosylated cytokines.