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Project: Affinity capillary electrochromatography and electrophoresis coupled with mass spectrometry for the screening of combinatorial libraries.

01-JAN-98 – 31-DEC-01

The aim of the project is the development of a fast screening technique for solution based combinatorial libraries. Affinity based electrodriven separation techniques like CZE and CEC are compared with pressure driven technique and hyphenation with MS is studied. Optimisation is done using vancomycin and interacting peptides, the best technique is used on a tetrapodal library and an HIV-I receptor.