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Project: Investigation of the biological role of alpha1-acidglycoprotein by means of the generation of SGP disrupted mice.

project duration
01-OCT-96 – 30-SEP-00
abstract
Alpha-acid glycoprotein is an acute phase protein in most mammalian species. The biological function of this protein is not known, although there are some indications that it plays an anti inflammatory role. For example, it conferes protection against a lethal injection of tumor necrosis factor (TNF). To study the biological function of alpha1-SGP, we will generate and study DGP-knock-out mice.